Prof. Christine Ziegler
Prof. Christine Ziegler
Integrative Structural Biology Core Group Member, LINXS Fellow
My group focuses on the structure and function of membrane proteins and macromolecular complexes, which are involved in stress-regulated and stress-activated transport processes across the membrane.
Besides X-ray crystallography, SAXS, and electron microscopy we apply a variety of different biophysical and biochemical techniques to characterize the function of membrane proteins in order to elucidate their molecular mechanism.
The main research interests of my group concern the study of macromolecular systems using physical techniques. Neutron and X-ray scattering techniques at the Institut Laue Langevin (ILL) and the European Synchrotron Radiation Facility (ESRF) are central to this. Current project work includes structural studies of DNA, DNA-drug interactions and DNA-protein complexes, self assembling systems of synthetic and biological origin.
We are also deeply involved in methodological developments for neutron and X-ray scattering. The Integrated Macromolecular Structure Research Group is based at the Partnership for Structural Biology (PSB) in Grenoble, France, where a wide variety of techniques are available to complement the capabilities of the Grenoble central facility infrastructures. For further details, see (http://www.ill.fr/deuteration).