Chemistry of Life Core Group leader, LINXS Fellow

Andrew Hudson, Professor of Biophysical Chemistry, Institute for Structural and Chemical Biology, University of Leicester, UK.

Prof Hudson is a biophysical chemist with research interests in the application of specialised techniques in fluorescence imaging to monitor the dynamics of single molecules. He has been applying these methods to address otherwise inaccessible problems in RNA splicing. These have included validation of the spice-site selection model and the pathways for the early stages of spliceosome assembly and 3′ splice-site selection. On a different note, he has applied a number of different imaging modalities to quantifying the distribution of haem proteins in living cells, and how this evolves in response to different stimuli. Recently, he has been looking at the regulatory role of haem in cells, and designed a genetically-encoded sensor for measuring in vivo haem concentrations by fluorescence lifetime imaging. His research group has also developed new fluorescence assays to probe the role of haem in the molecular mechanism of the transcription-translation feedback loops which are responsible for maintaining circadian rhythms.