Recorded talk: Video

Speaker: Mikael Lund, Lund University, Sweden (replacing Christina Bergonzo, NIST, USA)

Title: Little-known Interactions Between Proteins

Abstract:

Protein-protein interactions (PPIs) are important for biological function as well as for a range of technical applications including food formulation and vaccine development. This presentation gives an introduction to the multitude of weak, non-bonded intermolecular forces that contribute to PPIs, and how these are affected by solution conditions. We briefly cover the origin of van der Waals forces; hydrophobic interactions; electrostatics; and ionic screening. We then proceed with a deeper dive into important, but lesser-known corners of the field. This includes salting in and out, i.e. Hofmeister series; the effect of multivalent ions; and inter-protein fluctuation forces due to acid/base equilibria.

Bio:

ML's area of expertise is in (bio-)physical chemistry with focus on aqueous electrolyte solutions. He has studied protein-protein; protein-ion; and protein-surface interactions using experiment, theory, and computer simulations.

Website: https://www.teokem.lu.se/~mikael

Some webinars are recorded to be used for educational purposes in the LINXS website.

By registering to our events you give your permission to LINXS, according to the General Data Protection Regulation (GDPR), to register your name and e-mail address to be used for the sole purpose of distributing newsletters and communications on LINXS activities.